Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378030 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
A high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.
Graphical abstractA high-throughput screening campaign of a library of 100,000 lead-like compounds identified 2-iminobenzimidazoles (L) as a novel class of trypanothione reductase inhibitors. These 2-iminobenzimidazoles display potent trypanocidal activity against Trypanosoma brucei rhodesiense, do not inhibit closely related human glutathione reductase and have low cytotoxicity against mammalian cells.Figure optionsDownload full-size imageDownload as PowerPoint slide