| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378036 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischemia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress at the cell membrane.
Graphical abstractWe designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that a synthesized probe 1 localized and detected oxidative stress in the cell membrane in an activated macrophage-like cell line.Figure optionsDownload full-size imageDownload as PowerPoint slide
