| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378111 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. γ-Hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
Graphical abstractThe synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. γ-Hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ana Conejo-Garcia, Christopher J. Schofield,