Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378114 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Novel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays.
Graphical abstractNovel variants of HIV-1 replication inhibitors of the styrylquinoline class harboring aroyl/acyl group at the C-7 position have been synthesized. In sharp contrast with styrylquinolines bearing a carboxylic acid group at C-7, these compounds proved to be inactive toward HIV-1 integrase in in vitro assays.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Marie Normand-Bayle, Christophe Bénard, Fatima Zouhiri, Jean-François Mouscadet, Hervé Leh, Claire-Marie Thomas, Gladys Mbemba, Didier Desmaële, Jean d’Angelo,