| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378115 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
Optimization of the biological activity of a new class of non-peptidyl, pyridazinone derived human melanocortin subtype-4 receptor agonists is disclosed.
Graphical abstractOptimization of the biological activity of a new class of non-peptidyl, pyridazinone derived human melanocortin subtype-4 receptor agonists is disclosed. This work culminated in the identification of 26, 63, and 67, which are potent and subtype selective agonists of human MC4R.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Feroze Ujjainwalla, Daniel Warner, Christine Snedden, Ricky D. Grisson, Thomas F. Walsh, Matthew J. Wyvratt, Rubana N. Kalyani, Tanya MacNeil, Rui Tang, David H. Weinberg, Lex Van der Ploeg, Mark T. Goulet,