| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378124 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Metabotropic glutamate receptor 2 (mGluR2) has been implicated in a variety of CNS disorders, including schizophrenia. Disclosed herein is the development of a new series of allosteric potentiators of mGluR2. Structure-activity relationship studies in conjunction with pharmacokinetic data led to the discovery of indole 5, which is active in an animal model for schizophrenia.
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Authors
Steven P. Govek, Celine Bonnefous, John H. Hutchinson, Theodore Kamenecka, Jeffrey McQuiston, Richard Pracitto, Lucy X. Zhao, Michael F. Gardner, Joyce K. James, Lorrie P. Daggett, Blake A. Rowe, Hervé Schaffhauser, Linda J. Bristow, Una C. Campbell,