| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378193 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate functional activity.
Graphical abstractThe first carbohydrate-free aminoglycoside analogs bearing the 2-deoxystreptamine moiety were synthesized from asymmetrically protected 2-deoxystrepamine and subsequently demonstrated to have significant binding to the 16S A-site rRNA target and moderate functional activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaojing Wang, Michael T. Migawa, Kristin A. Sannes-Lowery, Eric E. Swayze,