| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378202 | Bioorganic & Medicinal Chemistry Letters | 2005 | 6 Pages |
Abstract
The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
Graphical abstractThe structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianchang Li, Thomas S. Rush III, Wei Li, Dianne DeVincentis, Xuemei Du, Yonghan Hu, Jennifer R. Thomason, Jason S. Xiang, Jerauld S. Skotnicki, Steve Tam, Kristina M. Cunningham, Priya S. Chockalingam, Elisabeth A. Morris, Jeremy I. Levin,