| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378209 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
2,5-Dihydro-3H-pyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands, which can exhibit functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimize this functional selectivity are described.
Graphical abstract2,5-Dihydro-3H-pyrazolo[4,3-c]pyridin-3-ones are GABAA receptor benzodiazepine binding site ligands, which can exhibit functional selectivity for the α3 subtype over the α1 subtype. SAR studies to optimize this functional selectivity are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wesley P. Blackaby, John R. Atack, Frances Bromidge, Richard Lewis, Michael G.N. Russell, Alison Smith, Keith Wafford, Ruth M. McKernan, Leslie J. Street, José L. Castro,