| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378214 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A novel series of indolin-2-ones having a spirocyclic piperidine ring at the 3-position was synthesized and found to bind with high affinity to the ORL-1 receptor. Structure–activity relationships at the piperidine nitrogen were investigated. Substitution on the phenyl ring and nitrogen atom of the indolin-2-one core generated several selective high-affinity ligands that were antagonists of the ORL-1 receptor.
Graphical abstractSynthesis and SAR of a series of indolin-2-ones provided compounds with high affinity for the ORL-1 receptor.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gilles C. Bignan, Kathleen Battista, Peter J. Connolly, Michael J. Orsini, Jingchun Liu, Steven A. Middleton, Allen B. Reitz,