| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378217 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. Compound 5 was selected for in vivo testing in the db/db mouse model of type 2 diabetes and resulted in reduction of hyperglycemia at comparable plasma exposure when compared to rosiglitazone.
Graphical abstractA series of novel aryl indole-2-carboxylic acids has been identified as potent selective PPARγ modulators. Their chemical synthesis and in vitro activities are discussed. An optimized compound was efficacious in the db/db mouse model of type 2 diabetes.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James F. Dropinski, Taro Akiyama, Monica Einstein, Bahanu Habulihaz, Tom Doebber, Joel P. Berger, Peter T. Meinke, Guo Q. Shi,