| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378220 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A novel high-yielding and environment-friendly synthesis of the anticancer compound 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid is described. This compound was conjugated to H2N-Ala-Pro dipeptide to give a prodrug to be activated by intestinal ACE and to be used in the treatment of different forms of colon cancer. Data on the chemical and enzymatic stability of this novel prodrug are reported.
Graphical abstractThe synthesis of a novel colon ACE targeted prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Massimo Curini, Francesco Epifano, Salvatore Genovese,