| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378221 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
The synthesis of two caffeoyl-coumarin conjugates, derived from sagecoumarin, has been accomplished, starting from ferulic acid, isoferulic acid and sesamol. Both compounds exhibited potent inhibitory activities at micromolar concentrations against HIV-1 integrase in 3′-end processing reaction but were less effective against HIV-1 replication in a single-round infection assay of HeLa-β-gal-CD4+ cells.
Graphical abstractTwo caffeoyl-coumarin conjugates derived from sagecoumarin were synthesized and exhibited potent micromolar inhibitory potencies against HIV-1 integrase in 3′-end processing reaction but were less effective against HIV-1 replication.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fabrice Bailly, Clémence Queffelec, Gladys Mbemba, Jean-François Mouscadet, Philippe Cotelle,