| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378227 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
N-Acetyl-S-farnesyl cysteine (AFC) is the minimal synthetic substrate for the enzyme Icmt, which methylates prenylated proteins. The desthio-AFC isostere 2 has been synthesized in racemic form. This analog was not an Icmt substrate, but instead a weak inhibitor with an IC50 of ∼325 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brian S. Henriksen, Jessica L. Anderson, Christine A. Hrycyna, Richard A. Gibbs,