Article ID Journal Published Year Pages File Type
1378230 Bioorganic & Medicinal Chemistry Letters 2005 5 Pages PDF
Abstract

The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38α is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.

Graphical abstractThe structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors 4 with selectivity against JNK1 and p38α is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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