Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378230 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors with selectivity against JNK1 and p38α is reported. The novel series of substituted 6-anilinoindazoles were designed based on a combination of hits from high throughput screening and X-ray crystal structure information of the compounds crystallized into the JNK3 ATP binding active site.
Graphical abstractThe structure-based design and synthesis of a new series of c-Jun N-terminal kinase-3 inhibitors 4 with selectivity against JNK1 and p38α is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Britt-Marie Swahn, Fernando Huerta, Elisabet Kallin, Jonas Malmström, Tatjana Weigelt, Jenny Viklund, Patrick Womack, Yafeng Xue, Liselotte Öhberg,