| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378256 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Incorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides (α-ON) allows high-affinity targeting of complementary DNA for α-ON with anionic and neutral backbone but not for cationic α-ON, revealing clues on the role of the amino group of the propynylamino on the formation of DNA duplexes.
Graphical abstractIncorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides (α-ON) allows high-affinity targeting of complementary DNA for anionic and neutral but not for cationic α-ON.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gaëlle Deglane, François Morvan, Françoise Debart, Jean-Jacques Vasseur,