| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378259 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1 ± 0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.
Graphical abstractThe development of a FEZ-1 metallo-β-lactamase inhibitor.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Benoît M.R. Liénard, Louise E. Horsfall, Moreno Galleni, Jean-Marie Frère, Christopher J. Schofield,