13C bis-labeled pyrroles: A tool for the identification of the rat metabolism of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester

Following the recent disclosure of 3-methyl pyrrole-2,4-dicarboxylic acid 2-propyl ester 4-(1,2,2-trimethyl-propyl) ester as a potent and selective mGluR1 non-competitive antagonist, the use of a doubly 13C-labeled analogue to identify, and consequently prevent, metabolically labile positions is reported.

Graphical abstractInvestigation on the metabolic fate of the pyrrole mGluR1 antagonist class is presented.Figure optionsDownload full-size imageDownload as PowerPoint slide