| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378261 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A novel class of 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase is described. This report discusses the SAR of 4-(2-hydroxy-2-phenylethylamino)-substituted pyridones with improved IGF-1R potency.
Graphical abstractA novel class of benzimidazole–pyridone inhibitors of insulin-like growth factor I (IGF-1R) kinase is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mark D. Wittman, Balu Balasubramanian, Karen Stoffan, Upender Velaparthi, Pieying Liu, Subramaniam Krishnanathan, Joan Carboni, Aixin Li, Ann Greer, Ricardo Attar, Marco Gottardis, Chiehying Chang, Bruce Jacobson, Yax Sun, Steven Hansel, Mary Zoeckler,