| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378276 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of novel 4-aryl-1,2,3,4-tetrahydroisoquinoline-based histamine H3 ligands that also have serotonin reuptake transporter inhibitor activity is described. The synthesis, in vitro biological data, and select pharmacokinetic data for these novel compounds are discussed.
Graphical abstractNovel histamine H3 antagonists with serotonin reuptake activity are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael A. Letavic, John M. Keith, Jill A. Jablonowski, Emily M. Stocking, Leslie A. Gomez, Kiev S. Ly, Jennifer M. Miller, Ann J. Barbier, Pascal Bonaventure, Jamin D. Boggs, Sandy J. Wilson, Kirsten L. Miller, Brian Lord, Heather M. McAllister,