| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378277 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The design and synthesis of dual PPAR γ/δ agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Isabel C. Gonzalez, Jason Lamar, Fatima Iradier, Yanping Xu, Leonard L. Winneroski, Jeremy York, Nathan Yumibe, Richard Zink, Chahrzad Montrose-Rafizadeh, Gary J. Etgen, Carol L. Broderick, Brian A. Oldham, Nathan Mantlo,