| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378279 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A series of furoxan-based nitric oxide-releasing glucocorticoid derivatives was synthesized. The pharmacological assays indicated that three compounds, including I4, I5, and I6, had anti-inflammatory activity. Furthermore compared with the leading compound hydrocortisone the safety of I6 was greatly improved. Due to releasing NO in vivo the side effects of glucocorticoids, including hypertension and osteoporosis, were effectively avoided.
Graphical abstractA series of furoxan-based nitric oxide-releasing glucocorticoid derivatives was synthesized and evaluated for their anti-inflammatory activity and safety.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lei Fang, Yihua Zhang, Jochen Lehmann, You Wang, Hui Ji, Dayong Ding,