| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378282 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively.
Graphical abstractA series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized, and compounds 6d and 6e showed strong cytotoxicity against three human cancer cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chang-Ming Sun, Lee-Gin Lin, Hsi-Jung Yu, Chih-Yu Cheng, Ya-Chuan Tsai, Chi-Wei Chu, Yi-Hui Din, Yat-Pang Chau, Ming-Jaw Don,