Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378345 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicated that it was nicely accommodated by AChE.
Graphical abstractA series of 2-phenoxy-indan-1-one derivatives have been designed, synthesized, and tested as acetylcholinesterase inhibitors. The most potent compound exhibited high AChE inhibitory activity (IC50 = 50 nM), and the molecular docking study indicates that it was nicely accommodated by AChE.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rong Sheng, Xiao Lin, Jingya Li, Yanke Jiang, Zhicai Shang, Yongzhou Hu,