Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378353 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
7-Aryl-6,7-dihydroimidazoimidazoles represent a novel series of high-affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis and SAR as well as behavioral activity of two exemplary compounds, 7b and 7k, in a mouse canopy model of anxiety.
Graphical abstractThe synthesis and SAR of constrained dihydroimidazoimidazoles, and behavioral activity of compounds 7b (Ki 42 nM) and 7k (Ki 41 nM) in a mouse canopy model of anxiety, are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xiaojun Han, Jodi A. Michne, Sokhom S. Pin, Kevin D. Burris, Lynn A. Balanda, Lawrence K. Fung, Tracey Fiedler, Kaitlin E. Browman, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik,