| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378355 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The inhibition of cyclin-dependent kinase 4 (Cdk4) causes cell cycle arrest and restores a checkpoint that is absent in the majority of tumor cells. Compounds that inhibit Cdk4 selectively are targeted for treating cancer. Appropriate substitution of 2-aminoquinazolines is demonstrated to produce high levels of selectivity for Cdk4 versus closely related serine-threonine kinases.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yadagiri Bathini, Inderjit Singh, Patricia J. Harvey, Paul R. Keller, Rajeshwar Singh, Ronald G. Micetich, David W. Fry, Ellen M. Dobrusin, Peter L. Toogood,