| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378358 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ho-Jane Shue, Xiao Chen, Neng-Yang Shih, David J. Blythin, Sunil Paliwal, Ling Lin, Danlin Gu, John H. Schwerdt, Sapna Shah, Gregory A. Reichard, John J. Piwinski, Ruth A. Duffy, Jean E. Lachowicz, Vicki L. Coffin, Fei Liu, Amin A. Nomeir,