| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378371 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
5-Nitrobenzimidazole derivatives with varying substituents at 2-position have been designed, synthesized, and evaluated for angiotensin II antagonistic activity. A drug–receptor interaction model has been proposed.
Graphical abstract5-Nitrobenzimidazole coupled through a methylene linker to biphenyl carboxylic acid has been synthesized and evaluated for angiotensin II antagonism activity. On the basis of their higher activity over standard compounds, a binding profile for benzimidazole-based compounds has been proposed. Alkyl group at 2-position has also been optimized with respect to 5-substituent.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alka Bali, Yogita Bansal, M. Sugumaran, Jatinder Singh Saggu, P. Balakumar, Gurpreet Kaur, Gulshan Bansal, Ajay Sharma, Manjeet Singh,