| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378445 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A novel glucose-conjugated paclitaxel 5 was synthesized using succinic acid as linker between 2′-paclitaxel and methyl 2′-glucopyranose. 5 has not only improved the pharmaceutical properties of paclitaxel, such as solubility and stability, but also enhanced the specific target delivery to MCF-7 cells without the cytotoxicity against normal cells. Therefore, the glucose conjugation may be potentially used in the targeted delivery of other drugs into cells via glucose transporters (GLUTs) for cancer therapy.
Graphical abstractThe synthesis of novel glucose-conjugated paclitaxel 5 for improving its property and specific targeted delivery to cancer cells is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Der-Zen Liu, Supachok Sinchaikul, Peddiahgari Vasu Govardhana Reddy, Meng-Yang Chang, Shui-Tein Chen,