| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378456 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described.
Graphical abstractA new series of 4-anilinopyrimidines has been synthesized and evaluated as JNK1 inhibitors. SAR studies led to the discovery of potent JNK1 inhibitors with good enzymatic activity as well as cellular potency represented by compound 2b. Kinase selectivity profile and the crystal structure of 2b are also described.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mei Liu, Sanyi Wang, Jill E. Clampit, Rebecca J. Gum, Deanna L. Haasch, Cristina M. Rondinone, James M. Trevillyan, Cele Abad-Zapatero, Elizabeth H. Fry, Hing L. Sham, Gang Liu,