Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378458 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
The design, synthesis, and SAR studies of ‘core’ variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was efficacious in a murine allergic inflammation model (ED50 ∼ 10 mg/kg).
Graphical abstractThe design, synthesis, and SAR studies of ‘core’ variations led to identification of novel, selective, and potent small molecule antagonist (22) of the CC chemokine receptor-4 (CCR4) with improved in vitro activity and liability profile. Compound 22 was efficacious in a murine allergic inflammation model (ED50 10 mg/kg).Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Ashok V. Purandare, Honghe Wan, John E. Somerville, Christine Burke, Wayne Vaccaro, XiaoXia Yang, Kim W. McIntyre, Michael A. Poss,