Diaryl substituted pyrazoles as potent CCR2 receptor antagonists

We have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2. Structure–activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).

Graphical abstractWe have identified and synthesized a series of diaryl substituted pyrazoles as potent antagonists of the chemokine receptor subtype 2b. Structure–activity relationship studies directed toward improving the potency led to the discovery of 23 (IC50 = 6 nM).Figure optionsDownload full-size imageDownload as PowerPoint slide