| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378486 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.
Graphical abstractSAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity of a series of MCH-R1 antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kenneth M. Meyers, Nicholas Kim, José L. Méndez-Andino, X. Eric Hu, Rashid N. Mumin, Sean R. Klopfenstein, John A. Wos, Maria C. Mitchell, Jennifer L. Paris, David C. Ackley, Jerry K. Holbert, Scott W. Mittelstadt, Ofer Reizes,