Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378491 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Using solid phase-assisted synthesis and purification, a 49 member library of analogs of the mammary tumor chemopreventive retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been prepared. After prescreening for growth inhibitory activity in human mammary tumor cells (MCF-7) in culture, most of those analogs which showed activity (12 of them) were assayed for apoptosis-inducing activity in the MCF-7 cells. At least 3 of the analogs (13, 24, and 28) showed activity approaching that of 4-HPR.
Graphical abstractSolid phase synthesis of a small retinamide library and screening for mammary tumor cell growth inhibition are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Serena M. Mershon, Allyson L. Anding, Jason S. Chapman, Margaret Clagett-Dame, Laura A. Stonerock, Robert W. Curley Jr.,