| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378505 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.
Graphical abstractA novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa, HCT116, and A375 tumor cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Ronghui Lin, Yanhua Lu, Steven K. Wetter, Peter J. Connolly, Ignatius J. Turchi, William V. Murray, Stuart L. Emanuel, Robert H. Gruninger, Angel R. Fuentes-Pesquera, Mary Adams, Niranjan Pandey, Sandra Moreno-Mazza, Steven A. Middleton,