| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378510 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Novel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines (A2780, A2780/AD10).
Graphical abstractNovel, simplified analogues of the microtubule-stabilizing anticancer agent laulimalide, including the first derivatives with unnatural side chains, were designed by molecular modelling, synthesized by a late-stage diversification strategy, and evaluated in vitro for growth inhibition of human ovarian carcinoma cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slide
