Solid-phase synthesis and antibacterial evaluations of N-demethylvancomycin derivatives

Twenty-five N-demethylvancomycin derivatives were synthesized on solid-support and their structures were determined by LC–MS/MS. Biological evaluation of these compounds indicated that bulky hydrophobic substituent on vancosamine of N-demethylvancomycin can increase antibacterial activity against vancomycin-resistant Enterococcus faecalis.

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