| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378528 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A novel caspase-3 substrate N-Ac-DEVD-N′-MC-R110, which is a fluorogenic substrate cleavable in a single step, has been prepared. It has a significantly higher enzyme turnover rate and sensitivity for detecting caspase-3 activity both in solution and living cells than existing fluorogenic substrates.
Graphical abstractThe title compound is a single step cleavage fluorogenic substrate and has significantly higher enzyme turnover rate and sensitivity than existing fluorogenic substrates for detecting caspase-3 activity both in solution and living cells.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi-Qiang Wang, Jinfang Liao, Zhenjun Diwu,