| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378535 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
We have found that both enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns. This enantiomeric flexibility is in contrast to a previously reported 3-alkoxymethyl-4-arylpiperidine scaffold.
Graphical abstractBoth enantiomeric configurations of the 6-alkoxymethyl-1-aryl-2-piperazinone scaffold display equipotent renin inhibition activity and similar SAR patterns.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Noel A. Powell, Emma H. Clay, Daniel D. Holsworth, John W. Bryant, Michael J. Ryan, Mehran Jalaie, Erli Zhang, Jeremy J. Edmunds,