| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378536 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
The synthesis of racemic 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3â²,4â²:4,5]furo[3,2-b]pyridine-6,8(7H)-diones 1-6 having strong in vivo efficacy against the parasitic nematode Haemonchus contortus Rudolphi in sheep is described. After separation of the racemic compound 2 by HPLC the absolute configuration of the most anthelmintically active (4aS,5aS,8aS,8bR)-enantiomer 2a was determined by single crystal X-ray analysis using its (4aS,5aS,8aS,8bR)-2a-CuCl2 (2:1)-complex.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and anthelmintic activity of 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3â²,4â²:4,5]furo[3,2-b]pyridine-6,8(7H)-diones](/preview/png/1378536.png "First Page Preview: Synthesis and anthelmintic activity of 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3â²,4â²:4,5]furo[3,2-b]pyridine-6,8(7H)-diones")
Authors
Peter Jeschke, Achim Harder, Winfried Etzel, Wolfgang Gau, Axel Göhrt, Jordi Benet-Buchholz, Gerhard Thielking,