| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378540 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants, carbon-chain extension, and hydroxyl-functional group addition/deletions of DPD. The compilation of these studies reveals a binding cleft that can accommodate a number of different structural variants of DPD, albeit with invariably lower activities.
Graphical abstractSession adjourned! DPD analogs fail to produce quorum.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Colin A. Lowery, Kathleen M. McKenzie, Longwu Qi, Michael M. Meijler, Kim D. Janda,