| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378541 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
4-Aryl-3-pyridyl and 4-aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-α) inhibitors, which contain a novel isoxazolone five-membered heterocyclic core are described. Many showed sub-micromolar activity against lipopolysaccharide-induced TNF-α production.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Steven K. Laughlin, Michael P. Clark, Jane F. Djung, Adam Golebiowski, Todd A. Brugel, Mark Sabat, Roger G. Bookland, Matthew J. Laufersweiler, John C. VanRens, Jennifer A. Townes, Biswanath De, Lily C. Hsieh, Susan C. Xu, Richard L. Walter,