Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378571 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
A series of 4 functionalized head-to-head-linked hairpin oligo(N-methylpyrrole) carboxamides with different linkers have been synthesized. Their ability to bind double-stranded DNA and sequence specificity were compared and the apparent Kd values of their DNA complexes were determined. These compounds, particularly those with iminodiacetic linkers, revealed a high affinity for DNA (Kd = 4.5–4.8 × 10−9 M) and sequence specific recognition of 9–10 base pairs.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ludovic Halby, Vladimir A. Ryabinin, Alexandre N. Sinyakov, Alexandre S. Boutorine,