Article ID Journal Published Year Pages File Type
1378571 Bioorganic & Medicinal Chemistry Letters 2005 5 Pages PDF
Abstract

A series of 4 functionalized head-to-head-linked hairpin oligo(N-methylpyrrole) carboxamides with different linkers have been synthesized. Their ability to bind double-stranded DNA and sequence specificity were compared and the apparent Kd values of their DNA complexes were determined. These compounds, particularly those with iminodiacetic linkers, revealed a high affinity for DNA (Kd = 4.5–4.8 × 10−9 M) and sequence specific recognition of 9–10 base pairs.

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Physical Sciences and Engineering Chemistry Organic Chemistry
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