Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378578 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
In silico modelling was used to guide the positioning of the fluorescent dye NBD-F on the cannabinoid CB2 receptor agonist JWH-015. While the ultimate fluorescent conjugate lost extensive binding affinity to the cannabinoid CB2 receptor, affinity and efficacy studies on the naphthoyl 3-position modified precursor molecules have provided new insight into structure–activity relationships associated with this position.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew S. Yates, Stephen W. Doughty, David A. Kendall, Barrie Kellam,