Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378584 | Bioorganic & Medicinal Chemistry Letters | 2005 | 5 Pages |
Abstract
Novel curcumin mimics with asymmetrical units phenyl group with alkyl amide, chloro-substituted benzamide, or heteroaromatic amide moieties were synthesized and their anti-angiogenic activity was evaluated with the proliferation and tube formation inhibitory activity on the human umbilical vein endothelial cells. Compounds 5, 14, 17, and 18 showed potent growth inhibitory activity and tube formation inhibitory activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ho Bum Woo, Woon-Seob Shin, Seokjoon Lee, Chan Mug Ahn,