Article ID Journal Published Year Pages File Type
1378585 Bioorganic & Medicinal Chemistry Letters 2005 4 Pages PDF
Abstract

A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.

Graphical abstractA new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 which was co-crystallized with MMP-12.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
, , , , , , , , , , , , , ,