Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1378585 | Bioorganic & Medicinal Chemistry Letters | 2005 | 4 Pages |
Abstract
A new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Modeling studies using a known MMP-12 crystal structure identified a new interaction mode for these new MMP-12 inhibitors. Further optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 and which was co-crystallized with MMP-12.
Graphical abstractA new class of MMP-12 inhibitors was discovered and optimized using structure-based drug design methods. Optimization resulted in the discovery of a compound displaying nanomolar activity against MMP-12 which was co-crystallized with MMP-12.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Anne-Claude Dublanchet, Pierre Ducrot, Charles Andrianjara, Margaret O’Gara, Renaud Morales, Delphine Compère, Alexis Denis, Stéphane Blais, Philippe Cluzeau, Karine Courté, Jacques Hamon, François Moreau, Marie-Laure Prunet, Anita Tertre,