| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378652 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Two natural triterpenoid saponins bearing N-acetylglucosamine, lotoidoside D and lotoidoside E, which had been available only from Glinus lotoides growing in Egyptian desert, were facilely synthesized from readily available oleanolic acid. Preliminary pharmacological research showed their antitumor activity against HeLa cell.
Graphical abstractTwo antiproliferative triterpenoid saponins bearing N-acetylglucosamine were facilely synthesized. Antitumor activity was preliminarily investigated (IC50 = 2.74 μM against HeLa cell).Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mao-Cai Yan, Yang Liu, Hong Chen, Ying Ke, Qing-Chun Xu, Mao-Sheng Cheng,