| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378655 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A variety of 4-N atom substituted derivatives were synthesized and evaluated for their in vitro anticancer activities using 4-methylpiperazine-1-carbodithioic acid 3-cyano-3,3-diphenyl-propyl ester 4 as lead compound. Among them, compound 6a without any substituent on 4-N atom (R1 = H) was found to be the most active anticancer agent with IC50 = 5.3 μM against HL-60 and IC50 = 11.5 μM against Bel-7402, respectively. Increase in the polarity and/or introduction of suitable acyl groups at the 4-N atom of the lead compound 4 are favorable for the improvement of activity.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xueling Hou, Zemei Ge, Tingmin Wang, Wei Guo, Jingrong Cui, Tieming Cheng, Chingshan Lai, Runtao Li,