| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378657 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A large series of alkyl C-glycosides was synthesized from d-glucal or d-galactal. These compounds were screened against the human promyelocytic leukemia cell line (HL60), showing significant activity and apoptosis. Up to 13 C-glucopyranosides, but no C-galacto- or C-mannopyranosides, exhibited inhibitory concentrations (IC50 values) below 20 μM, five of them in the range 4–8 μM. Preliminary structure–activity relationships were established.
Graphical abstractA large series of alkyl C-glycosides was synthesized and screened against the human promyelocytic leukemia cell line (HL60), showing significant activity and apoptosis.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carlos A. Sanhueza, Carlos Mayato, María García-Chicano, Raquel Díaz-Peñate, Rosa L. Dorta, Jesús T. Vázquez,