| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378660 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.
Graphical abstractA series of substituted chromones were designed, synthesized, and evaluated for their ability to bind melanin-concentrating hormone receptor 1. Compounds with subnanomolar binding affinity and 66% oral bioavailability in rats were discovered.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Brian Dyck, Liren Zhao, Junko Tamiya, Joseph Pontillo, Sarah Hudson, Brett Ching, Christopher E. Heise, Jenny Wen, Christi Norton, Ajay Madan, David Schwarz, Warren Wade, Val S. Goodfellow,